Article

BRCA2 chaperones RAD51 to single molecules of RPA-coated ssDNA

2022-12-29

Abstract excerpt

Mutations in the breast cancer susceptibility gene, BRCA2, greatly increase an individual’s lifetime risk of developing breast and ovarian cancers. BRCA2 suppresses tumor formation by potentiating DNA repair via homologous recombination. Central to recombination is the assembly of a RAD51 nucleoprotein filament, which forms on single-stranded DNA (ssDNA) generated at or near the site of chromosomal damage. However...

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Literature Corpus work: ea0eba87-fe3b-55d4-9eac-acd6a0897882
DOI: 10.1101/2022.12.28.522061

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