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Article

Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.

Nucleic acids research - 4 May 2018

Špírek Mário, Mlcoušková Jarmila, Belán Ondrej, Gyimesi Máté, Harami Gábor M, Molnár Eszter, Novacek Jiri, Kovács Mihály, Krejci Lumir

Abstract excerpt

Formation of RAD51 filaments on single-stranded DNA is an essential event during homologous recombination, which is required for homology search, strand exchange and protection of replication forks. Formation of nucleoprotein filaments (NF) is required for development and genomic stability, and its failure is associated with developmental abnormalities and tumorigenesis. Here we describe the structure of the...

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Share to Adenine Nucleotides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29481689
DOI: 10.1093/nar/gky111
PMCID: PMC5934667

Genes

RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.PMID 29481689Read ↗

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.Semantic proximity Read ↗

Structural mechanism of strand exchange by the RAD51 filamentSemantic proximity Read ↗

The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.Semantic proximity Read ↗

Local structural dynamics of Rad51 protomers revealed by cryo-electron microscopy of Rad51-ssDNA filamentsSemantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filamentSemantic proximity Read ↗

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.Semantic proximity Read ↗

Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombinationSemantic proximity Read ↗

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.Semantic proximity Read ↗

Insights into the mechanism of Rad51 recombinase from the structure and properties of a filament interface mutant.Semantic proximity Read ↗

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activitySemantic proximity Read ↗

Crystal structure of a Rad51 filament.Semantic proximity Read ↗

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