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Structure and function of the RAD51B–RAD51C–RAD51D–XRCC2 tumour suppressor

21 Jun 2023

Abstract excerpt

Homologous recombination is a fundamental process of life. It is required for the protection and restart of broken replication forks, the repair of chromosome breaks and the exchange of genetic material during meiosis. Individuals with mutations in key recombination genes, such as BRCA2 (also known as FANCD1), or the RAD51 paralogues RAD51B, RAD51C (also known as FANCO), RAD51D, XRCC2 (also known as FANCU) and...

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PMID: 37344587
DOI: 10.1038/s41586-023-06179-1

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