Article
BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability.
Molecular cell - 5 Jun 2025
Longo Michael A, Ahmed Syed Moiz, Chen Yue, Tsai Chi-Lin, Namjoshi Sarita, Shen Runze, Ahmed Zamal, Wang Xiaoyan, Perera Rajika L, Arvai Andy, Lee Miyoung, Kong Li Ren, Engl Wilfried, Ng Woei Shyuan, Zhao Ziqing Winston, Venkitaraman Ashok R, Tainer John A, Schlacher Katharina
Abstract excerpt
Tumor suppressor protein breast cancer susceptibility protein 2 (BRCA2) acts with RAD51 in replication fork protection (FP) and homology-directed DNA-break repair (HDR). Critical for cancer etiology and therapy resistance, the BRCA2 C terminus was thought to stabilize recombinogenic RAD51 after the assembly of ATP-extended RAD51 filaments on single-stranded DNA (ssDNA). Here, the detailed crystal structure of the...
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