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Article

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.

Cell - 16 Jul 2015

Taylor Martin R G, Špírek Mário, Chaurasiya Kathy R, Ward Jordan D, Carzaniga Raffaella, Yu Xiong, Egelman Edward H, Collinson Lucy M, Rueda David, Krejci Lumir, Boulton Simon J

Abstract excerpt

Repair of DNA double strand breaks by homologous recombination (HR) is initiated by Rad51 filament nucleation on single-stranded DNA (ssDNA), which catalyzes strand exchange with homologous duplex DNA. BRCA2 and the Rad51 paralogs are tumor suppressors and critical mediators of Rad51. To gain insight into Rad51 paralog function, we investigated a heterodimeric Rad51 paralog complex, RFS-1/RIP-1, and uncovered the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26186187
DOI: 10.1016/j.cell.2015.06.015
PMCID: PMC4518479

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.PMID 26186187Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.Semantic proximity Read ↗

Rad51 paralog complex Rad55–Rad57 acts as a molecular chaperone during homologous recombinationSemantic proximity Read ↗

The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.Semantic proximity Read ↗

Novel insights into RAD51 activity and regulation during homologous recombination and DNA replicationSemantic proximity Read ↗

RAD51 Gene Family Structure and FunctionSemantic proximity Read ↗

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.Semantic proximity Read ↗

Human RAD51 paralogue, SWSAP1, fosters RAD51 filament by regulating the anti-recombinase, FIGNL1 AAA+ ATPaseSemantic proximity Read ↗

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.Semantic proximity Read ↗

Phosphoregulation of RAD51AP1 function in homology-directed repair.Semantic proximity Read ↗

Structural mechanism of strand exchange by the RAD51 filamentSemantic proximity Read ↗

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