Article

Finding ancestry-specific chromatin architecture in Alzheimer’s disease

2025-08-20

Abstract excerpt

Genetic risk for Alzheimer’s Disease (AD) varies across populations. We hypothesized that three-dimensional (3D) genome architecture variations could offer novel epigenetic understanding of ancestry-specific genetic risk. Herein, we performed Hi-C analyses of frontal cortex from APOE ε4/ε4 individuals with African (AF) or European (EU) ancestry who also had single nuclei ATAC-seq and RNA-seq data available. Ances...

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Literature Corpus work: e9fcf9df-806b-5147-bdb7-82a48601499b
DOI: 10.1101/2025.08.19.671054

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