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Article

Interplay Between 3D Chromatin Architecture and Gene Regulation at the APOE Locus Contributes to Alzheimer's Disease Risk.

International journal of molecular sciences - 27 Dec 2025

Lee Eun-Gyung, Leong Lesley, Chen Sunny, Tulloch Jessica, Yu Chang-En

Abstract excerpt

The ε4 allele of the apolipoprotein E (APOE) gene strongly increases Alzheimer's disease (AD) risk, though its molecular mechanisms remain unclear. AD-associated genetic signals also extend to neighboring genes TOMM40 and APOC1, suggesting a complex cis-regulatory landscape. To investigate chromatin architecture and its impact on gene regulation across this region, we performed chromosome conformation capture in...

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Source

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Identifiers

PMID: 41516176
DOI: 10.3390/ijms27010302
PMCID: PMC12785688

Genes

APOE
APOC1
TOMM40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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