Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease.

doi:10.1002/alz.70593

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Article

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Ramirez Aura M, Nasciben Luciana Bertholim, Moura Sofia, Coombs Lauren, Rajabli Farid, DeRosa Brooke A, Whitehead Patrice L, Adams Larry D, Starks Takiyah D, Mena Pedro R, Illanes-Manrique Maryenela, Tejada Sergio, Byrd Goldie S, Caban-Holt Allison, Cuccaro Michael L, McInerney Katalina, Cornejo-Olivas Mario R, Feliciano-Astacio Briseida E, Wang Liyong, Robayo Maria C, Xu Wanying, Jin Fulai, Pericak-Vance Margaret A, Griswold Anthony J, Young Juan I, Dykxhoorn Derek M, Vance Jeffery M

Abstract excerpt

INTRODUCTION: This study investigates ancestry-specific changes in induced pluripotent stem cell (iPSC)-derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS: We generated 12 iPSC lines from AD patients and controls with different apolipoprotein E (APOE) genotypes, APOE ε3/ ε3 and APOE...

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PMID: 40937943
DOI: 10.1002/alz.70593
PMCID: PMC12426912

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APOE

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