Article

GWAS for serum galactose-deficient IgA1 implicates critical genes of the <i>O</i> -glycosylation pathway

2016-09-21

Abstract excerpt

Aberrant O -glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of glomerulonephritis worldwide, but specific genetic factors involved in its determination are not known. We performed a quantitative GWAS for serum levels of galactose-deficient IgA1 (Gd-IgA1) in 2,633 subjects of European and East Asian ancestry and discovered two genome...

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Literature Corpus work: e950bf9f-0465-570a-aa42-8761790bf2cb
DOI: 10.1101/076414

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