Article

Genetic Evaluation of the Role of Galactose-Deficient IgA1 in IgA Nephropathy: Evidence from Association Testing and Mendelian Randomization

2025-10-28

Abstract excerpt

Elevated galactose deficient IgA1 (Gd-IgA1) is known to be associated with IgA nephropathy (IgAN) and is often regarded as the first of four steps in the “four hit” hypothesis to explain disease pathogenesis. However, while the proposed downstream hits have support from unbiased genetic association studies, similar genetic evidence to support a causal role for Gd-IgA1 in the disease is lacking. Multiple previous g...

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Literature Corpus work: 472a4983-82df-5d66-b9a5-39bc393f8226
DOI: 10.1101/2025.10.25.25338806

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