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The genetics and epidemiology of N- and O-immunoglobulin A glycomics

9 Aug 2024

Abstract excerpt

BACKGROUND: Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylation. METHODS: We generated, using a novel liquid chromatography-mass spectrometry method, the first large-scale IgA glycomics dataset in serum from 2423 twins,...

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PMID: 39123268
DOI: 10.1186/s13073-024-01369-6

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