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Article

Aberrant IgA1 Glycosylation Is Inherited in Familial and Sporadic IgA Nephropathy

13 Feb 2008

Abstract excerpt

IgA nephropathy (IgAN) is a complex trait determined by genetic and environmental factors. Most IgAN patients exhibit a characteristic undergalactosylation of the O-glycans of the IgA1 hinge region, which promotes formation and glomerular deposition of immune complexes. It is not known whether this aberrant glycosylation is the result of an acquired or inherited defect, or whether the presence of aberrant IgA1...

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PMID: 18272841
DOI: 10.1681/asn.2007091052

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