Article
Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.
Journal of the American Society of Nephrology : JASN - 1 Mar 2021
Wang Yan-Na, Zhou Xu-Jie, Chen Pei, Yu Gui-Zhen, Zhang Xue, Hou Ping, Liu Li-Jun, Shi Su-Fang, Lv Ji-Cheng, Zhang Hong
Abstract excerpt
BACKGROUND: Galactose-deficient IgA1 plays a key role in the pathogenesis of IgA nephropathy, the most common primary GN worldwide. Although serum levels of galactose-deficient IgA1 have a strong genetic component, the genetic link between this molecule and IgA nephropathy has not yet been clearly established. METHODS: To identify novel loci associated with galactose-deficient IgA1, we performed a quantitative...
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