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Article

Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1.

Journal of the American Society of Nephrology : JASN - 1 Jul 2017

Gale Daniel P, Molyneux Karen, Wimbury David, Higgins Patricia, Levine Adam P, Caplin Ben, Ferlin Anna, Yin Peiran, Nelson Christopher P, Stanescu Horia, Samani Nilesh J, Kleta Robert, Yu Xueqing, Barratt Jonathan

Abstract excerpt

IgA nephropathy (IgAN), an important cause of kidney failure, is characterized by glomerular IgA deposition and is associated with changes in O-glycosylation of the IgA1 molecule. Here, we sought to identify genetic factors contributing to levels of galactose-deficient IgA1 (Gd-IgA1) in white and Chinese populations. Gd-IgA1 levels were elevated in IgAN patients compared with ethnically matched healthy subjects...

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Share to Galactose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genome-Wide Association Study

Share to Glomerulonephritis, IGA

Share to Glycosylation

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Share to Renal Diseases and Glomerulopathies

Source

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Identifiers

PMID: 28209808
DOI: 10.1681/ASN.2016091043
PMCID: PMC5491291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1.PMID 28209808Read ↗

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