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Article

Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy.

Journal of the American Society of Nephrology : JASN - 1 May 2012

Serino Grazia, Sallustio Fabio, Cox Sharon N, Pesce Francesco, Schena Francesco P

Abstract excerpt

Aberrant O-glycosylation in the hinge region of IgA1 characterizes IgA nephropathy. The mechanisms underlying this abnormal glycosylation are not well understood, but reduced expression of the enzyme core 1, β1,3-galactosyltransferase 1 (C1GALT1) may contribute. In this study, high-throughput mic...

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Share to Adolescent
Share to Galactosyltransferases
Share to Glomerulonephritis, IGA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Immunoglobulin A

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Share to Polymorphism, Single Nucleotide

Share to Renal Diseases and Glomerulopathies

Source

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Identifiers

PMID: 22362909
DOI: 10.1681/ASN.2011060567
PMCID: PMC3338289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22362909-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy.PMID 22362909Read ↗

GWAS for serum galactose-deficient IgA1 implicates critical genes of the <i>O</i> -glycosylation pathwaySemantic proximity Read ↗

C1GALT1 expression is associated with galactosylation of IgA1 in peripheral B lymphocyte in immunoglobulin A nephropathySemantic proximity Read ↗

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GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.Semantic proximity Read ↗

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microRNA-630 Regulates Underglycosylated IgA1 Production in the Tonsils by Targeting TLR4 in IgA NephropathySemantic proximity Read ↗

Interaction between GALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.Semantic proximity Read ↗

Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathySemantic proximity Read ↗

Galactosylation of IgA1 Is Associated with Common Variation in C1GALT1.Semantic proximity Read ↗

Genetics and immunopathogenesis of IgA nephropathy.Semantic proximity Read ↗

MiR‐320 promotes B cell proliferation and the production of aberrant glycosylated IgA1 in IgA nephropathySemantic proximity Read ↗

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