Article
GWAS for serum galactose-deficient IgA1 implicates critical genes of the O-glycosylation pathway.
PLoS genetics - 1 Feb 2017
Kiryluk Krzysztof, Li Yifu, Moldoveanu Zina, Suzuki Hitoshi, Reily Colin, Hou Ping, Xie Jingyuan, Mladkova Nikol, Prakash Sindhuri, Fischman Clara, Shapiro Samantha, LeDesma Robert A, Bradbury Drew, Ionita-Laza Iuliana, Eitner Frank, Rauen Thomas, Maillard Nicolas, Berthoux Francois, Floege Jürgen, Chen Nan, Zhang Hong, Scolari Francesco, Wyatt Robert J, Julian Bruce A, Gharavi Ali G, Novak Jan
Abstract excerpt
Aberrant O-glycosylation of serum immunoglobulin A1 (IgA1) represents a heritable pathogenic defect in IgA nephropathy, the most common form of glomerulonephritis worldwide, but specific genetic factors involved in its determination are not known. We performed a quantitative GWAS for serum levels of galactose-deficient IgA1 (Gd-IgA1) in 2,633 subjects of European and East Asian ancestry and discovered two...
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