Article

Species-specific chromatin architecture and neurogenesis mediated by a human enhancer

2025-08-08

Abstract excerpt

Genomic modifications underlie the evolution of human features, including a larger neocortex and enhanced cognition. Human Accelerated Regions (HARs) are highly-conserved loci containing human-specific variants and can act as neurodevelopmental enhancers. However, the neurodevelopmental functions of HARs and their mechanism of gene regulation are largely unknown. Here, we show that human ( Hs ) HAR1984 promotes...

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Literature Corpus work: e898646e-e674-50ff-a4ca-a8b3f9704c44
DOI: 10.1101/2025.08.08.669395

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