Article

Single-cell genomic atlas of great ape cerebral organoids uncovers human-specific features of brain development

2019-06-27

Abstract excerpt

<h4>ABSTRACT</h4> The human brain has changed dramatically since humans diverged from our closest living relatives, chimpanzees and the other great apes 1–5 . However, the genetic and developmental programs underlying this divergence are not fully understood 6–8 . Here, we have analyzed stem cell-derived cerebral organoids using single-cell transcriptomics (scRNA-seq) and accessible chromatin profiling (scATAC-...

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Literature Corpus work: 743897ca-ea69-5da6-9ec6-ed91ecc84b10
DOI: 10.1101/685057

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