Article

Long-Range Enhancer Networks Gradually Emerge as Key Regulators During Human Cortical Neurogenesis

2024-07-25

Abstract excerpt

The chromatin in the human brain cortex shows more enhancer-enhancer contacts than in macaques and mice, yet the organization of these contacts across cellular states and their mechanisms remain unclear. Here, we developed SCOPE-C, a cost-effective technique designed for mapping DNase I Hypersensitive Sites and their spatial interactions, with the potential for scalability to single-cell resolution. Employing SCOP...

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Literature Corpus work: 17bdab95-1b76-5ed8-bdee-992433cd43b7
DOI: 10.1101/2024.07.24.605026

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