Article

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopment

2018-01-29

Abstract excerpt

Using machine learning (ML), we interrogated the function of all human-chimpanzee variants in 2,645 Human Accelerated Regions (HARs), some of the fastest evolving regions of the human genome. We predicted that 43% of HARs have variants with large opposing effects on chromatin state and 14% on neurodevelopmental enhancer activity. This pattern, consistent with compensatory evolution, was confirmed using massively p...

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Literature Corpus work: 75779959-1f37-583d-907f-6f1f9d1f0b6c
DOI: 10.1101/256313

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