Article

Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopment

2024-06-26

Abstract excerpt

Human Accelerated Regions (HARs) are highly conserved across species but exhibit a significant excess of human-specific sequence changes, suggesting they may have gained novel functions in human evolution. HARs include transcriptional enhancers with human-specific activity and have been implicated in the evolution of the human brain. However, our understanding of how HARs contributed to uniquely human features of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 29f519b3-1f7c-5de1-a195-9e26aa75f6a6
DOI: 10.1101/2024.06.25.600691

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resolving the three-dimensional interactome of Human Accelerated Regions during human and chimpanzee neurodevelopmentDOI 10.1101/2024.06.25.600691Read

Species-specific chromatin architecture and neurogenesis mediated by a human enhancerSemantic proximity Read

Human Accelerated Regions regulate gene networks implicated in apical-to-basal neural progenitor fate transitionsSemantic proximity Read

Three-dimensional genome re-wiring in loci with Human Accelerated RegionsSemantic proximity Read

Massively parallel discovery of human-specific substitutions that alter neurodevelopmental enhancer activitySemantic proximity Read

Machine-learning dissection of Human Accelerated Regions in primate neurodevelopmentSemantic proximity Read

Mechanistically Distinct Pathways of Divergent Regulatory DNA Creation Contribute to Evolution of Human-Specific Genomic Regulatory Networks Driving Phenotypic Divergence of Homo sapiens.Semantic proximity Read

A human-specific enhancer fine-tunes radial glia potency and corticogenesisSemantic proximity Read

A Human Accelerated Region participates in early human forebrain patterning and expansionSemantic proximity Read

Revealing the transcription factor regulatory context of human specific cortical development using single-cell multi-omicsSemantic proximity Read

Long-Range Enhancer Networks Gradually Emerge as Key Regulators During Human Cortical NeurogenesisSemantic proximity Read

3D Epigenome Evolution Underlies Divergent Gene Regulatory Programs in Primate Neural DevelopmentSemantic proximity Read

Co-regulatory changes in <i>Homo sapiens</i> prefrontal cortex shape RNA-chromatin interactionsSemantic proximity Read