Article

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesis

2023-09-21

Abstract excerpt

The cellular and genetic mechanism underlying the human-specific features of cortex development remains unclear. We generated a cell-type resolved atlas of transcriptome and regulome of the developing macaque and mouse prefrontal cortex, and conducted evolutionary analyses with the published complementary human data. We discovered a primate-specific expansion of two neural progenitor subclasses, glia-committed rad...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ad4e4de-b6f3-56f0-b1e7-18155c1737d5
DOI: 10.1101/2023.09.20.558575

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesisDOI 10.1101/2023.09.20.558575Read

Coupled transcriptomic divergence establishes a human-specific synaptic glial precursor stateSemantic proximity Read

Dynamic landscapes of gene regulatory networks in early mammalian neurogenesis: Insights into brain evolution and disorder riskSemantic proximity Read

Temporal transcriptomic dynamics in developing macaque neocortexSemantic proximity Read

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortexSemantic proximity Read

Post-translational Tuning of Human Cortical Progenitor Neuronal OutputSemantic proximity Read

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortexSemantic proximity Read

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolutionSemantic proximity Read

Orthogonal Modes of Gene Expression Evolution Shape Human Neocortical Development and Disease VulnerabilitySemantic proximity Read

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brainsSemantic proximity Read

Single-cell transcriptomic analysis identifies neocortical developmental differences between human and mouseSemantic proximity Read

Comparative primate transcriptomics identifies a ZNF90–OVOL2 regulatory axis shaping human neural progenitor cell dynamicsSemantic proximity Read

Evolution of regulatory signatures in primate cortical neurons at cell type resolutionSemantic proximity Read