Article

Retromer stabilization using a pharmacological chaperone protects in an α-synuclein based mouse model of Parkinson’s

2023-10-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> In the present study we assessed the protective effects of a pharmacological approach to stabilize the retromer complex in a PD mouse model. Missense mutations in the VPS35 gene are a rare cause of familial PD. The VPS35 protein is a subunit of the retromer cargo recognition complex and has a variety of functions within neurons, many of which are potentially rele...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e826a011-d5d8-5ef7-be1f-897e0f30eff2
DOI: 10.21203/rs.3.rs-3417076/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Retromer stabilization using a pharmacological chaperone protects in an α-synuclein based mouse model of Parkinson’sDOI 10.21203/rs.3.rs-3417076/v1Read

Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer’s DiseaseSemantic proximity Read

VPS35 and α-Synuclein Fail to Interact to Modulate Neurodegeneration in Rodent Models of Parkinson’s DiseaseSemantic proximity Read

Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapySemantic proximity Read

A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell modelSemantic proximity Read

Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy.Semantic proximity Read

Divalent siRNA for prion diseaseSemantic proximity Read

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged miceSemantic proximity Read

Beneficial Effect of a Small Pharmacologic Chaperone on the Established Alzheimer's Disease Phenotype.Semantic proximity Read

Direct detection of alpha synuclein oligomers in vivoSemantic proximity Read

Restoring Parkin Function: An AAV Gene Therapy Approach for Early-Onset Parkinson’s DiseaseSemantic proximity Read

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.Semantic proximity Read

A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2 ) 66 mouse modelSemantic proximity Read