Article

Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy

2021-07-27

Abstract excerpt

<title>Abstract</title> <p>Anxiety and depression affect 35–50% of patients with Parkinson's disease (PD), often precede the onset of motor symptoms, and have a negative impact on their quality of life. Dysfunction of the serotonergic (5-HT) system, which regulates mood and emotional pathways, occurs during the premotor phase of PD and contributes to a variety of non-motor symptoms. Furthermore, α-synuclein (α-Sy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a765309-aad7-54dd-8bbc-61ae5482f209
DOI: 10.21203/rs.3.rs-725067/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapyDOI 10.21203/rs.3.rs-725067/v1Read

Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy.Semantic proximity Read

Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons.Semantic proximity Read

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotypeSemantic proximity Read

Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neuronsSemantic proximity Read

Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype.Semantic proximity Read

Modeling Parkinson’s Disease With the Alpha-Synuclein ProteinSemantic proximity Read

Early synaptic changes and reduced brain connectivity in PD-like mice with depressive phenotypeSemantic proximity Read

Accelerated and Localized Synucleinopathy in a Hybrid Mouse Model: Implications for Positron Emission Tomography StudiesSemantic proximity Read

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and InterventionSemantic proximity Read

How can <scp>rAAV</scp>‐α‐synuclein and the fibril α‐synuclein models advance our understanding of Parkinson's disease?Semantic proximity Read

Up-And-Down γ-Synuclein Transcription in Dopamine Neurons Translates Into Changes in Dopamine Neurotransmission and Behavioral Performance in MiceSemantic proximity Read

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectorsSemantic proximity Read