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Article

Beneficial Effect of a Small Pharmacologic Chaperone on the Established Alzheimer's Disease Phenotype.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Li Jian-Guo, Blass Benjamin E, Praticò Domenico

Abstract excerpt

BACKGROUND: The endosomal retromer complex system is a key controller for trafficking of proteins. Downregulation of its recognition core proteins, such as VPS35, is present in Alzheimer's disease (AD) brain, whereas its normalization prevents the development of AD pathology in a transgenic model with amyloid-β deposits and tau tangles. OBJECTIVE: Assess the effect of targeting VPS35 after the AD pathology and...

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Source

Identifiers

PMID: 36442197
DOI: 10.3233/JAD-220869

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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