Article

A genome-wide RNA interference screening reveals protectiveness of SNX5 knockdown in a Parkinson’s disease cell model

2024-03-14

Abstract excerpt

<h4>Background</h4> Alpha-synuclein is a major player in the pathophysiology of a group of diseases called synucleinopathies, which include Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. To date, there is no disease-modifying therapy available for these synucleinopathies. Furthermore, the intracellular mechanisms by which alpha-synuclein confers toxicity are not yet fully understood....

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Literature Corpus work: 887fdf71-a862-5c65-ba0b-ffcbe7f0b433
DOI: 10.1101/2024.03.13.584847

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