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Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer’s Disease

2024-06-11

Abstract excerpt

Synaptic dysfunction is an early hallmark of Alzheimer’s disease, characterized by the disruption of synaptic transmission and plasticity. Central to these processes is endosomal trafficking, mediated by the retromer complex, which orchestrates the movement of vesicle contents for recycling to the plasma membrane, return to the Golgi, or degradation. Variants of VPS35, the cargo recognition component of the retrom...

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Literature Corpus work
b37f4ab0-796c-5b43-a163-da91c1a876e3
DOI
10.1101/2024.06.11.598446
Open publication

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Enhancing Retromer Complex Stability Ameliorates Synaptic Dysfunction in a Mouse Model of Alzheimer’s DiseaseDOI 10.1101/2024.06.11.598446
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