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Article

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.

PloS one - 10 Nov 2010

Shaltiel-Karyo Ronit, Frenkel-Pinter Moran, Egoz-Matia Nirit, Frydman-Marom Anat, Shalev Deborah E, Segal Daniel, Gazit Ehud

Abstract excerpt

The intracellular oligomerization of α-synuclein is associated with Parkinson's disease and appears to be an important target for disease-modifying treatment. Yet, to date, there is no specific inhibitor for this aggregation process. Using unbiased systematic peptide array analysis, we identified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21085664
DOI: 10.1371/journal.pone.0013863
PMCID: PMC2978097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21085664-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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