Article
Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy.
Translational psychiatry - 24 Feb 2022
Miquel-Rio Lluis, Alarcón-Arís Diana, Torres-López María, Cóppola-Segovia Valentín, Pavia-Collado Rubén, Paz Verónica, Ruiz-Bronchal Esther, Campa Leticia, Casal Carme, Montefeltro Andrés, Vila Miquel, Artigas Francesc, Revilla Raquel, Bortolozzi Analia
Abstract excerpt
Anxiety and depression affect 35-50% of patients with Parkinson's disease (PD), often precede the onset of motor symptoms, and have a negative impact on their quality of life. Dysfunction of the serotonergic (5-HT) system, which regulates mood and emotional pathways, occurs during the premotor phase of PD and contributes to a variety of non-motor symptoms. Furthermore, α-synuclein (α-Syn) aggregates were...
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