Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct detection of alpha synuclein oligomers in vivo

9 May 2013

Abstract excerpt

BACKGROUND: Rat models of Parkinson's disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches. Models were developed using toxins such as MPTP or 6-OHDA to specifically target dopaminergic neurons resulting in acute neuronal loss in the substantia nigra or by using viral vectors to induce the specific and gradual expression of alpha synuclein in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Nerve injury and regeneration
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24252244
DOI: 10.1186/2051-5960-1-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct detection of alpha synuclein oligomers in vivoPMID 24252244Read ↗

In vivo demonstration that α-synuclein oligomers are toxicSemantic proximity Read ↗

Modeling Parkinson’s Disease With the Alpha-Synuclein ProteinSemantic proximity Read ↗

Bimolecular Fluorescence Complementation of Alpha-synuclein Demonstrates its Oligomerization with Dopaminergic Phenotype in Mice.Semantic proximity Read ↗

Viral overexpression of human alpha-synuclein in mouse substantia nigra dopamine neurons results in hyperdopaminergia but no neurodegenerationSemantic proximity Read ↗

How can <scp>rAAV</scp>‐α‐synuclein and the fibril α‐synuclein models advance our understanding of Parkinson's disease?Semantic proximity Read ↗

A Versatile AAV-TH-SNCA Model to Study Early α-Synuclein Pathology and InterventionSemantic proximity Read ↗

Targeted Overexpression of α-Synuclein by rAAV2/1 Vectors Induces Progressive Nigrostriatal Degeneration and Increases Vulnerability to MPTP in MouseSemantic proximity Read ↗

Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal SystemSemantic proximity Read ↗

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.Semantic proximity Read ↗

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.Semantic proximity Read ↗

Viral Vector Mediated Overexpression of Human α-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's DiseaseSemantic proximity Read ↗

AAV Vector-Mediated Gene Delivery to Substantia Nigra Dopamine Neurons: Implications for Gene Therapy and Disease ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.