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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2 ) 66 mouse model

2024-12-10

Abstract excerpt

<title>Abstract</title> <p>The G<sub>4</sub>C<sub>2</sub> hexanucleotide repeat expansion in <italic>C9ORF72</italic> is the major genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9-ALS/FTD). Despite considerable efforts, the development of mouse models of C9-ALS/FTD useful for therapeutic development has proven challenging due to the intricate interplay of genetic and...

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Literature Corpus work
e5ce646d-6618-56ef-9330-e90d2850f21c
DOI
10.21203/rs.3.rs-5221595/v1
Open publication

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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2 ) 66 mouse modelDOI 10.21203/rs.3.rs-5221595/v1
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