Article

Altered striatal dopamine levels in Parkinson’s disease VPS35 D620N mutant transgenic aged mice

2020-12-03

Abstract excerpt

<title>Abstract</title> <p>Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that mediates the retrograde transport of cargo proteins from endosomes to the trans-Golgi network. Mutations such as D620N in the VPS35 gene have been identified in patients with autosomal dominant Parkinson’s disease (PD). However, it remains poorly understood whether and how VPS35 deficiency or mutation...

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Literature Corpus work: 274c6519-39e6-537a-889b-2f03e86b06f3
DOI: 10.21203/rs.3.rs-51781/v3

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