Article

VPS35 and α-Synuclein Fail to Interact to Modulate Neurodegeneration in Rodent Models of Parkinson’s Disease

2022-12-07

Abstract excerpt

Mutations in the vacuolar protein sorting 35 ortholog ( VPS35 ) gene cause late-onset, autosomal dominant Parkinson’s disease (PD), with a single missense mutation (Asp620Asn, D620N) known to segregate with disease in families with PD. The VPS35 gene encodes a core component of the retromer complex, involved in the endosomal sorting and recycling of transmembrane cargo proteins. VPS35 -linked PD is clinically...

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Literature Corpus work: 78c7018a-03d0-5457-b66f-8437d62a04fc
DOI: 10.1101/2022.12.07.519521

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