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The La Crosse virus Gc head domain is a major determinant of virus dissemination and pathogenesis

2025-05-12

Abstract excerpt

How orthobunyaviruses establish infections and disseminate to cause disease is not well understood. In a previous study using the in vivo evolution of La Crosse virus (LACV), we discovered a cluster of mutations localizing to the LACV Gc head domain. However, we do not understand how the Gc head domain contributes to infection. We generated each of the aforementioned mutations and addressed the role of the Gc hea...

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Identifiers and source

Literature Corpus work
e81f3374-307d-5ed3-a932-73835ace5d26
DOI
10.1101/2025.05.12.653523
Open publication

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The La Crosse virus Gc head domain is a major determinant of virus dissemination and pathogenesisDOI 10.1101/2025.05.12.653523
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