Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

La Crosse virus (LACV) Gc fusion peptide mutants have impaired growth and fusion phenotypes, but remain neurotoxic.

Virology - 1 Sept 2010

Soldan Samantha S, Hollidge Bradley S, Wagner Valentina, Weber Friedemann, González-Scarano Francisco

Abstract excerpt

La Crosse virus is a leading cause of pediatric encephalitis in the Midwestern United States and an emerging pathogen in the American South. The LACV glycoprotein Gc plays a critical role in entry as the virus attachment protein. A 22 amino acid hydrophobic region within Gc (1066-1087) was recently identified as the LACV fusion peptide. To further define the role of Gc (1066-1087) in virus entry, fusion, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cricetinae
Share to Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Phenotype

Share to Viral Fusion Proteins

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 20553924
DOI: 10.1016/j.virol.2010.04.012
PMCID: PMC2919166

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

La Crosse virus (LACV) Gc fusion peptide mutants have impaired growth and fusion phenotypes, but remain neurotoxic.PMID 20553924Read ↗

Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis.Semantic proximity Read ↗

Mutagenesis of the La Crosse Virus glycoprotein supports a role for Gc (1066–1087) as the fusion peptideSemantic proximity Read ↗

The La Crosse virus Gc head domain is a major determinant of infection and pathogenesis.Semantic proximity Read ↗

The La Crosse virus Gc head domain is a major determinant of virus dissemination and pathogenesisSemantic proximity Read ↗

Cysteines and N-Glycosylation Sites Conserved among All Alphaherpesviruses Regulate Membrane Fusion in Herpes Simplex Virus 1 Infection.Semantic proximity Read ↗

Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters.Semantic proximity Read ↗

Functional dissection of HCMV gB's autonomous fusion activity provides insights into how polymorphisms in clinical isolates confer distinct characteristics.Semantic proximity Read ↗

Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes.Semantic proximity Read ↗

Collective fusion activity determines neurotropism of an en bloc transmitted enveloped virus.Semantic proximity Read ↗

La Crosse virus reassortants highlight genomic determinants of infection and pathogenesisSemantic proximity Read ↗

Cell-to-Cell Measles Virus Spread between Human Neurons Is Dependent on Hemagglutinin and Hyperfusogenic Fusion ProteinSemantic proximity Read ↗

Herpes Simplex Virus 1 Glycoprotein B from a Hyperfusogenic Virus Mediates Enhanced Cell–Cell FusionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.