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Article

Mutations in the E2 Glycoprotein and the 3′ Untranslated Region Enhance Chikungunya Virus Virulence in Mice

26 Jul 2017

Abstract excerpt

ABSTRACT Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection. Although studies of humans and experimentally infected animals suggest that CHIKV infection persists in musculoskeletal tissues, the mechanisms for this remain poorly understood. To evaluate this further, we isolated CHIKV...

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PMID: 28747508
DOI: 10.1128/jvi.00816-17

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