Article
Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2011
Sullivan Brian M, Emonet Sébastien F, Welch Megan J, Lee Andrew M, Campbell Kevin P, de la Torre Juan C, Oldstone Michael B
Abstract excerpt
Arenaviruses are a major cause of hemorrhagic fevers endemic to Sub-Saharan Africa and South America, and thus a major public health and medical concern. The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) is widely used as a model system for studying persistent and acute infections, as well as for gaining an understanding of mammalian immune function. When originally characterized three decades...
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