Article

Emerging chikungunya virus variants at the E1-E1 inter-glycoprotein spike interface impact virus attachment and Inflammation

2021-09-14

Abstract excerpt

<h4>ABSTRACT</h4> Chikungunya virus (CHIKV) is a re-emerging arthropod-borne alphavirus and a serious threat to human health. Therefore, efforts toward elucidating how this virus causes disease and the molecular mechanisms underlying steps of the viral replication cycle are crucial. Using an in vivo transmission system that allows intra-host evolution, we identified an emerging CHIKV variant carrying a mutation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cde3ea21-f57a-5322-85a8-a811cb8f38e9
DOI: 10.1101/2021.09.13.460192

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Emerging chikungunya virus variants at the E1-E1 inter-glycoprotein spike interface impact virus attachment and InflammationDOI 10.1101/2021.09.13.460192Read

Emerging Chikungunya Virus Variants at the E1-E1 Interglycoprotein Spike Interface Impact Virus Attachment and Inflammation.Semantic proximity Read

Changes in the chikungunya virus E1 glycoprotein domain II and hinge influence E2 conformation, infectivity, and virus-receptor interactions.Semantic proximity Read

Chikungunya Virus Strains from Each Genetic Clade Bind Sulfated Glycosaminoglycans as Attachment FactorsSemantic proximity Read

Mutations in the E2 Glycoprotein and the 3′ Untranslated Region Enhance Chikungunya Virus Virulence in MiceSemantic proximity Read

Loss of Glycosaminoglycan Receptor Binding after Mosquito Cell Passage Reduces Chikungunya Virus InfectivitySemantic proximity Read

Evolution and immunopathology of chikungunya virus informs therapeutic development.Semantic proximity Read

Deep mutationally scanned (DMS) CHIKV E3/E2 virus library maps viral amino acid preferences and predicts viral escape mutants of neutralizing CHIKV antibodiesSemantic proximity Read

Structural Studies of Chikungunya Virus-Like Particles Complexed with Human Antibodies: Neutralization and Cell-to-Cell TransmissionSemantic proximity Read

Pathogenicity and virulence of chikungunya virusSemantic proximity Read

The La Crosse virus class II fusion glycoprotein <i>ij</i> loop contributes to infectivity and cholesterol-dependent entrySemantic proximity Read

Overview of Chikungunya Virus Pathogenesis, Genome Variation, Epidemiology, and Control.Semantic proximity Read

Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants.Semantic proximity Read