The La Crosse virus Gc head domain is a major determinant of infection and pathogenesis.

Abstract excerpt

How orthobunyaviruses establish infections and disseminate to cause disease is not well understood. In a previous study using the in vivo evolution of La Crosse virus (LACV), we discovered a cluster of mutations localizing to the LACV Gc head domain. However, we do not understand how the Gc head domain contributes to infection. Here, we generated each of the aforementioned mutations and addressed the role of the...

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