Article
Molecular characterization of Ebola virus glycoprotein V75A substitution in the 2018-2020 epidemic.
Cell - 5 Feb 2026
Fan Linjin, Wang Yulong, Wang Yinghao, Wang Zequn, Yang Xiaofeng, Liang Chudan, Yang Chongguang, Liu Nan, Zheng Jun, Kang Weifang, Ye Pengfei, Sun Pei, Shi Wendi, Guo Xinyi, Wu Weijian, Yang Jian-Rong, Liu Quan, Liu Linna, Qian Jun
Abstract excerpt
The 2018-2020 Ebola virus disease (EVD) epidemic facilitated the emergence of viral mutations, enhancing the potential for host adaptation during sustained human transmission. Here, we identified the Ebola virus (EBOV) glycoprotein V75A (GP-V75A) substitution as a dominant variant during the epidemic. This substitution, located within the receptor-binding domain, emerged early in the outbreak and rapidly reached...
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