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La Crosse virus reassortants highlight genomic determinants of infection and pathogenesis

2024-03-11

Abstract excerpt

The genomic determinants that contribute to orthobunyavirus infection and pathogenesis are not well-defined. In this study, we harnessed the process of reassortment to understand which viral factors drive change in the replication and pathogenesis of La Crosse virus (LACV). We systematically reassorted the genomic segments of two genetically similar Lineage I LACV isolates into six unique reassortants. Despite the...

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Identifiers and source

Literature Corpus work
1131aa65-e4f2-5144-87d9-ca58a1687d01
DOI
10.1101/2024.03.11.584386
Open publication

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La Crosse virus reassortants highlight genomic determinants of infection and pathogenesisDOI 10.1101/2024.03.11.584386
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