Article

A mix-and-match reverse genetics system for evaluating genetic determinants of orthobunyavirus neurological disease

2024-09-25

Abstract excerpt

<h4>ABSTRACT</h4> The encephalitic orthobunyaviruses have tri-segmented, negative sense RNA genomes and can cause severe neurological disease in humans, including La Crosse virus (LACV), which is the leading cause of pediatric arboviral encephalitis in the United States. However, little is known about the genetic factors that drive neuropathogenesis. Reverse genetics (RG) systems are valuable tools for studying v...

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Literature Corpus work: fa4c7749-2621-5a3b-89cc-9ae947ec87ad
DOI: 10.1101/2024.09.25.614932

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