Article

The <i>R1441C-LRRK2</i> mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

2023-10-17

Abstract excerpt

Considering age is the greatest risk factor for many neurodegenerative diseases, aging, in particular aging of the immune system, is the most underappreciated and understudied contributing factor in the neurodegeneration field. Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson’s disease (PD). The leucine-rich repeat kinase 2 (LRRK2) protein has been implicated in periphe...

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Literature Corpus work: e80e7571-cc63-5131-a682-52ff14ed45f7
DOI: 10.1101/2023.10.12.562063

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