Article

CD200R1 loss in CNS-associated macrophages triggers T cell-driven neurodegeneration in Parkinson’s disease

2025-08-11

Abstract excerpt

<title>Abstract</title> <p>Immune dysregulation is increasingly recognized as a key contributor to Parkinson’s disease (PD) pathogenesis. While microglia are established central nervous system (CNS) immune regulators, the role of CNS-associated macrophages (CAMs) and their upstream modulation by immune checkpoints remains poorly defined. Here, we identify CD200R1, a myeloid-specific inhibitory receptor, as a chec...

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Literature Corpus work: b1ec63d4-aa71-5b62-93a7-a92d3839d035
DOI: 10.21203/rs.3.rs-7253835/v1

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CD200R1 loss in CNS-associated macrophages triggers T cell-driven neurodegeneration in Parkinson’s diseaseDOI 10.21203/rs.3.rs-7253835/v1Read

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