Article

LRRK2 kinase dependent and independent function on endolysosomal repair promotes macrophage cell death

2023-09-27

Abstract excerpt

LRRK2 is commonly mutated in Parkinson’s disease and has cell type-specific mechanisms of activation and function. In macrophages, LRRK2 is associated with lysosomes and is activated following lysosomal damage. However, effects of pathogenic LRRK2-G2019S in macrophages are unknown. Here, using primary mouse and human iPSC-derived macrophage (iPSDM) models of LRRK2-G2019S, we defined the substrates of LRRK2 after l...

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Literature Corpus work: 2be17b80-c31f-5327-b2c4-a25abcada69a
DOI: 10.1101/2023.09.27.559807

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