Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.

doi:10.1007/s00702-011-0653-2

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Article

Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2011

Hakimi Mansoureh, Selvanantham Thirumahal, Swinton Erika, Padmore Ruth F, Tong Youren, Kabbach Ghassan, Venderova Katerina, Girardin Stephen E, Bulman Dennis E, Scherzer Clemens R, LaVoie Matthew J, Gris Denis, Park David S, Angel Jonathan B, Shen Jie, Philpott Dana J, Schlossmacher Michael G

Abstract excerpt

Sequence variants at or near the leucine-rich repeat kinase 2 (LRRK2) locus have been associated with susceptibility to three human conditions: Parkinson's disease (PD), Crohn's disease and leprosy. As all three disorders represent complex diseases with evidence of inflammation, we hypothesized a role for LRRK2 in immune cell functions. Here, we report that full-length Lrrk2 is a relatively common constituent of...

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PMID: 21552986
DOI: 10.1007/s00702-011-0653-2
PMCID: PMC3376651

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