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Totally tubular: ASO-mediated knock-down of <i>G2019S</i> -Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages

2023-07-15

Abstract excerpt

Genetic variation around the LRRK2 gene affects risk of both familial and sporadic Parkinson’s disease (PD). LRRK2 levels have become an appealing target for potential PD-therapeutics with LRRK2 antisense oligonucleotides (ASOs) now in clinical trials. However, LRRK2 has been suggested to play a fundamental role in peripheral immunity, and it is currently unknown if targeting increased LRRK2 levels in peripheral...

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Literature Corpus work
54549a31-2bef-5540-bbdf-982b46708a8d
DOI
10.1101/2023.07.14.549028
Open publication

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Totally tubular: ASO-mediated knock-down of <i>G2019S</i> -Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophagesDOI 10.1101/2023.07.14.549028
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