Article

Vps35 p. D620N causes Lrrk2 kinase hyperactivity, chronic microglial activation and inflammation

2026-03-11

Abstract excerpt

<h4>ABSTRACT</h4> Pathogenic variants in leucine-rich repeat kinase 2 (LRRK2), vacuolar protein sorting 35 (VPS35 ), and RAB32 cause dominantly inherited parkinsonism, indistinguishable from idiopathic late-onset Parkinson’s disease (PD). All three causes constitutively activate LRRK2 kinase activity to augment immune responses, enhancing immunity to fight pathogens, but similar mechanisms in the brain increase...

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Literature Corpus work: 1106f021-d902-593b-802e-a0084d3d9662
DOI: 10.64898/2026.03.09.710482

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