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LRRK2-G2019S Synergizes with Ageing and Low-Grade Inflammation to Promote Gut and Peripheral Immune Cell Activation that Precede Nigrostriatal Degeneration

2022-09-03

Abstract excerpt

<h4>Background</h4> Mutations in the leucine-rich repeat kinase 2 ( LRRK2 ) gene are the most frequent cause of familial Parkinson’s disease (PD). The incomplete penetrance of LRRK2 mutations suggest that additional hits are required for disease onset. We hypothesized that chronic low-grade inflammation interacts with LRRK2 G2019S, the most frequent PD-associated mutation, to activate peripheral and central imm...

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Literature Corpus work: 048a7d71-edc2-5cdf-8696-a9c4aa7f7dce
DOI: 10.1101/2022.09.01.505977

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