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Article

LRRK2 and the Immune System.

Advances in neurobiology - 1 Jan 2017

Dzamko Nicolas L

Abstract excerpt

Polymorphisms in leucine-rich repeat kinase 2 (LRRK2) have been linked to familial Parkinson's disease, increased risk of sporadic Parkinson's disease, increased risk of Crohn's inflammatory bowel disease, and increased susceptibility to leprosy. As well as LRRK2 mutations, these diseases share in common immune dysfunction and inflammation. LRRK2 is highly expressed in particular immune cells and has been...

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PMID: 28353282
DOI: 10.1007/978-3-319-49969-7_7

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